Hepatotoxicity of isotretinoin in patients with acne and Gilbert's syndrome: a comparative study.

ABSTRACT:

Objectives

The objective of our follow-up study is to evaluate liver function tests (LFTs) and lipid profiles in patients with Gilbert's syndrome treated with isotretinoin because of severe acne.

Setting

Dermatology outpatient clinics of three regional hospitals of Jaén (Spain).

Participants

Over 4 years, we included all patients diagnosed with severe acne. Only 37 patients were identified, of which 11 had Gilbert's syndrome.

Interventions

All patients were treated with isotretinoin and followed-up in our outpatient clinics after 10 and 20 weeks. Patients were subjected to an interview questionnaire which included data on age, gender, complete blood count, coagulation profile, fasting blood glucose, LFTs and lipid profiles. Data and results of patients with sev

SUBMITTER: Fernandez-Crehuet P 

PROVIDER: S-EPMC3963066 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature