Systematic review and meta-analysis of opioid antagonists for smoking cessation.

ABSTRACT:

Objectives

This meta-analysis sought to evaluate the efficacy of opioid antagonists in promoting long-term smoking cessation. Post-treatment abstinence was examined as a secondary outcome and effects on withdrawal symptoms, craving and reduced consumption were also explored.

Design

The search strategy for this meta-analysis included clinical trials (published and unpublished data) in the Cochrane Tobacco Addiction Group Specialized Register and MEDLINE.

Participants

Adult smokers.

Interventions

We included randomised trials comparing opioid antagonists to placebo or an alternative therapy for smoking cessation and reported data on abstinence for a minimum of 6 months.

Primary and secondary outcome measures

Outcomes included smoking abstinence at long-ter

SUBMITTER: David SP 

PROVIDER: S-EPMC3963070 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature