An evolving understanding of nuclear receptor coregulator proteins.

ABSTRACT: Nuclear receptors are transcription factors that regulate gene expression through the ligand-controlled recruitment of a diverse group of proteins known as coregulators. Most nuclear receptor coregulators function in large multi-protein complexes that modify chromatin and thereby regulate the transcription of target genes. Structural and functional studies are beginning to reveal how these complexes are assembled bringing together multiple functionalities that mediate: recruitment to specific genomic loci through interaction with transcription factors; recruitment of enzymatic activities that either modify or remodel chromatin and targeting the complexes to their chromatin substrate. These activities are regulated by post-translational modifications, alternative splicing and small signalli

SUBMITTER: Millard CJ 

PROVIDER: S-EPMC3963257 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature