Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.

ABSTRACT:

Background

There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified six variants that influence disease risk. However, the interplay between such risk factors and susceptibility loci has not been studied.

Methods

Data from 14 ovarian cancer case-control studies were pooled, and stratified analyses by each environmental risk factor with tests for heterogeneity were conducted to determine the presence of interactions for all histologic subtypes. A genetic "risk score" was created to consider the effects of all six variants simultaneously. A multivariate model was fit to examine the association between all environmental risk factors and genetic risk score on ovarian cancer risk.

Results<

SUBMITTER: Pearce CL 

PROVIDER: S-EPMC3963289 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature