Timing of single-neuron and local field potential responses in the human medial temporal lobe.

ABSTRACT: The relationship between the firing of single cells and local field potentials (LFPs) has received increasing attention, with studies in animals [1-11] and humans [12-14]. Recordings in the human medial temporal lobe (MTL) have demonstrated the existence of neurons with selective and invariant responses [15], with a relatively late but precise response onset around 300 ms after stimulus presentation [16-18] and firing only upon conscious recognition of the stimulus [19]. This represents a much later onset than expected from direct projections from inferotemporal cortex [16, 18]. The neural mechanisms underlying this onset remain unclear. To address this issue, we performed a joint analysis of single-cell and LFP responses during a visual recognition task. Single-neuron responses were prece

SUBMITTER: Rey HG 

PROVIDER: S-EPMC3963414 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature