Individualized current-shaping reduces DBS-induced dysarthria in patients with essential tremor.

ABSTRACT:

Objective

To investigate in patients with essential tremor (ET) treated with thalamic/subthalamic deep brain stimulation (DBS) whether stimulation-induced dysarthria (SID) can be diminished by individualized current-shaping with interleaving stimulation (cs-ILS) while maintaining tremor suppression (TS).

Methods

Of 26 patients screened, 10 reported SID and were invited for testing. TS was assessed by the Tremor Rating Scale and kinematic analysis of postural and action tremor. SID was assessed by phonetic and logopedic means. Additionally, patients rated their dysarthria on a visual analog scale.

Results

In 6 of the 10 patients with ET, DBS-ON (relative to DBS-OFF) led to SID while tremor was successfully reduced. When comparing individualized cs-ILS with a non-curren

SUBMITTER: Barbe MT 

PROVIDER: S-EPMC3963416 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature