Cyclin D3 critically regulates the balance between self-renewal and differentiation in skeletal muscle stem cells.

ABSTRACT: Satellite cells are mitotically quiescent myogenic stem cells resident beneath the basal lamina surrounding adult muscle myofibers. In response to injury, multiple extrinsic signals drive the entry of satellite cells into the cell cycle and then to proliferation, differentiation, and self-renewal of their downstream progeny. Because satellite cells must endure for a lifetime, their cell cycle activity must be carefully controlled to coordinate proliferative expansion and self-renewal with the onset of the differentiation program. In this study, we find that cyclin D3, a member of the family of mitogen-activated D-type cyclins, is critically required for proper developmental progression of myogenic progenitors. Using a cyclin D3-knockout mouse we determined that cyclin D3 deficiency leads t

SUBMITTER: De Luca G 

PROVIDER: S-EPMC3963451 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature