Effects of lipid-lowering drugs on high-density lipoprotein subclasses in healthy men-a randomized trial.

ABSTRACT:

Context and objective

Investigating the effects of lipid-lowering drugs on HDL subclasses has shown ambiguous results. This study assessed the effects of ezetimibe, simvastatin, and their combination on HDL subclass distribution.

Design and participants

A single-center randomized parallel 3-group open-label study was performed in 72 healthy men free of cardiovascular disease with a baseline LDL-cholesterol of 111±30 mg/dl (2.9±0.8 mmol/l) and a baseline HDL-cholesterol of 64±15 mg/dl (1.7±0.4 mmol/l). They were treated with ezetimibe (10 mg/day, n = 24), simvastatin (40 mg/day, n = 24) or their combination (n = 24) for 14 days. Blood was drawn before and after the treatment period. HDL subclasses were determined using polyacrylamide gel-tube electrophoresis. Multivariate reg

SUBMITTER: Berthold HK 

PROVIDER: S-EPMC3963857 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature