Expression of the sFLT1 gene in cord blood cells is associated to maternal arsenic exposure and decreased birth weight.

ABSTRACT: There is increasing epidemiologic evidence that arsenic exposure in utero is associated with adverse pregnancy outcomes and may contribute to long-term health effects. These effects may occur at low environmental exposures but the underlying molecular mechanism is not clear. We collected cord blood samples of 183 newborns to identify associations between arsenic levels and birth anthropometric parameters in an area with very low arsenic exposure. Our core research aim was to screen for transcriptional marks that mechanistically explain these associations. Multiple regression analyses showed that birth weight decreased with 47 g (95% CI: 16-78 g) for an interquartile range increase of 0.99 μg/L arsenic. The model was adjusted for child's sex, maternal smoking during pregnancy, gestational a

SUBMITTER: Remy S 

PROVIDER: S-EPMC3963915 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature