Prostate stromal cells express the progesterone receptor to control cancer cell mobility.

ABSTRACT:

Background

Reciprocal interactions between epithelium and stroma play vital roles for prostate cancer development and progression. Enhanced secretions of cytokines and growth factors by cancer associated fibroblasts in prostate tumors create a favorable microenvironment for cancer cells to grow and metastasize. Our previous work showed that the progesterone receptor (PR) was expressed specifically in prostate stromal fibroblasts and smooth muscle cells. However, the expression levels of PR and its impact to tumor microenvironment in prostate tumors are poorly understood.

Methods

Immunohistochemistry assays are applied to human prostate tissue biopsies. Cell migration, invasion and proliferation assays are performed using human prostate cells. Real-time PCR and ELISA are appl

SUBMITTER: Yu Y 

PROVIDER: S-EPMC3963951 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature