CDKAL1 and HHEX are associated with type 2 diabetes-related traits among Yup'ik people.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D), mainly among individuals of European ancestry. In the present study, we examined the frequency of these SNPs and their association with T2D-related traits in an Alaska Native study population with a historically low prevalence of T2D. We also investigated whether dietary characteristics that may protect against T2D, such as n-3 polyunsaturated fatty acid (PUFA) intake, modify these associations.

Methods

In 1144 Yup'ik people, we examined 17 SNPs repeatedly identified in GWAS for individual and cumulative associations with T2D-related traits. Cumulative associations were evaluated using a genetic risk score (GRS) calculated by summing

SUBMITTER: Klimentidis YC 

PROVIDER: S-EPMC3964139 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature