Heritability of nociception IV: neuropathic pain assays are genetically distinct across methods of peripheral nerve injury.

ABSTRACT: Prior genetic correlation analysis of 22 heritable behavioral measures of nociception and hypersensitivity in the mouse identified 5 genetically distinct pain types. In the present study, we reanalyzed that dataset and included the results of an additional 9 assays of nociception and hypersensitivity, with the following goals: to replicate the previously identified 5 pain types; to test whether any of the newly added pain assays represent novel genetically distinct pain types; and to test the level of genetic relatedness among 9 commonly used neuropathic pain assays. Multivariate analysis of pairwise correlations between assays shows that the newly added zymosan-induced heat hypersensitivity assay does not conform to the 2 previously identified groups of heat hypersensitivity assays and cy

SUBMITTER: Young EE 

PROVIDER: S-EPMC3964153 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature