Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era.

ABSTRACT: In patients with an acute ST-segment elevation myocardial infarction, timely myocardial reperfusion using primary percutaneous coronary intervention is the most effective therapy for limiting myocardial infarct size, preserving left-ventricular systolic function and reducing the onset of heart failure. Within minutes after the restoration of blood flow, however, reperfusion itself results in additional damage, also known as myocardial ischemia-reperfusion injury. An improved understanding of the pathophysiological mechanisms underlying reperfusion injury has resulted in the identification of several promising pharmacological (cyclosporin-A, exenatide, glucose-insulin-potassium, atrial natriuretic peptide, adenosine, abciximab, erythropoietin, metoprolol and melatonin) therapeutic strategie

SUBMITTER: Dominguez-Rodriguez A 

PROVIDER: S-EPMC3964186 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature