Impact of donor-specific antibodies on the outcomes of kidney graft: Pathophysiology, clinical, therapy.

ABSTRACT: Allo-antibodies, particularly when donor specific, are one of the most important factors that cause both early and late graft dysfunction. The authors review the current state of the art concerning this important issue in renal transplantation. Many antibodies have been recognized as mediators of renal injury. In particular donor-specific-Human Leukocyte Antigens antibodies appear to play a major role. New techniques, such as solid phase techniques and Luminex, have revealed these antibodies from patient sera. Other new techniques have uncovered alloantibodies and signs of complement activation in renal biopsy specimens. It has been acknowledged that the old concept of chronic renal injury caused by calcineurine inhibitors toxicity should be replaced in many cases by alloantibodies acting

SUBMITTER: Salvadori M 

PROVIDER: S-EPMC3964192 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature