Ontology highlight
ABSTRACT:
SUBMITTER: Hiddingh L
PROVIDER: S-EPMC3964213 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Oncotarget 20140101 2
Glioblastoma is the most common malignant primary brain tumor. Temozolomide (TMZ) is the standard chemotherapeutic agent for this disease. However, intrinsic and acquired TMZ-resistance represents a major obstacle for this therapy. In order to identify factors involved in TMZ-resistance, we engineered different TMZ-resistant glioblastoma cell lines. Gene expression analysis demonstrated that EFEMP1, an extracellular matrix protein, is associated with TMZ-resistant phenotype. Silencing of EFEMP1 ...[more]