Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators.

ABSTRACT: The closely related transcription factors (TFs), estrogen receptors ERα and ERβ, regulate divergent gene expression programs and proliferative outcomes in breast cancer. Utilizing breast cancer cells with ERα, ERβ, or both receptors as a model system to define the basis for differing response specification by related TFs, we show that these TFs and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules. Cistrome and transcriptome analyses and the use of clustering algorithms delineated 11 clusters representing different chromatin-bound receptor and coregulator assemblies that could be functionally associated through enrichment analysis with distinct patterns of gene regulation and preferential coregulator usage

SUBMITTER: Madak-Erdogan Z 

PROVIDER: S-EPMC3964312 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature