Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.

ABSTRACT: The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

SUBMITTER: Wang X 

PROVIDER: S-EPMC3964319 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature