Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility.

ABSTRACT: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals. Genetic markers are associated with disease phenotype and long-term evolution, but their value in everyday clinical practice is limited at the moment. IBD has a clear immunological background and interleukins play key role in the process. Almost 130 original papers were revised including meta-analysis. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but text often do not available for the doctors use these in the clinical practice nowadays. We conducted a systematic review

SUBMITTER: Magyari L 

PROVIDER: S-EPMC3964393 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature