Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis.

ABSTRACT:

Background

Low-contrast letter acuity and optical coherence tomography (OCT) capture visual dysfunction and axonal loss in adult-onset multiple sclerosis (MS), and have been proposed as secondary outcome metrics for therapeutic trials. Clinical trials will soon be launched in pediatric MS, but such outcome metrics have not been well-validated in this population.

Objectives

To determine whether MS onset during childhood and adolescence is associated with measurable loss of visual acuity and thinning of the retinal nerve fiber layer (RNFL), whether such features are noted only in the context of clinical optic nerve inflammation (optic neuritis, ON) or are a feature of MS even in the absence of optic nerve relapses, and to define the optimal methods for such detection.

Study

SUBMITTER: Waldman AT 

PROVIDER: S-EPMC3964624 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature