FunCoup 3.0: database of genome-wide functional coupling networks.

ABSTRACT: We present an update of the FunCoup database (http://FunCoup.sbc.su.se) of functional couplings, or functional associations, between genes and gene products. Identifying these functional couplings is an important step in the understanding of higher level mechanisms performed by complex cellular processes. FunCoup distinguishes between four classes of couplings: participation in the same signaling cascade, participation in the same metabolic process, co-membership in a protein complex and physical interaction. For each of these four classes, several types of experimental and statistical evidence are combined by Bayesian integration to predict genome-wide functional coupling networks. The FunCoup framework has been completely re-implemented to allow for more frequent future updates. It conta

SUBMITTER: Schmitt T 

PROVIDER: S-EPMC3965084 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature