Correlation between single nucleotide polymorphisms of the ACTA2 gene and coronary artery stenosis in patients with type 2 diabetes mellitus.

ABSTRACT: This study aimed to analyze the correlation between single nucleotide polymorphisms (SNPs) of the actin, aortic smooth muscle (ACTA2) gene and coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). Eight SNPs from the promoter region of the ACTA2 gene were screened. Patients with T2DM (n=251) were divided into two groups, those with severe coronary stenosis (SCS⁺ group; n=168) and those without severe coronary stenosis (SCS^- group; n=83). Patients were also divided according to lesion branching into those whose lesions involved less than three branches (LCA^- group) and those whose lesions involved at least three branches (LCA⁺ group). The clinical and laboratory data of the patients were collected, and the genotyping of eight

SUBMITTER: Fang H 

PROVIDER: S-EPMC3965172 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature