Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time course of human diabetes.

ABSTRACT:

Background

Netrin-1 was recently identified as an early diagnostic biomarker of chronic kidney disease (CKD) in an experimental animal model. However, its usefulness for early diagnosis of CKD in humans is unknown. The current study evaluated whether netrin-1 is increased in urine from human diabetic patients.

Methods

Spot urine samples from healthy volunteers, diabetes without microalbuminuria, diabetes with microalbuminuria and diabetes with macroalbuminuria were collected after receiving consent. Netrin-1 in urine was quantified by enzyme-linked immunosorbent assay and the data analyzed to determine whether urinary netrin-1 significantly correlates with disease progression.

Results

Urinary netrin-1 levels were significantly increased in normoalbuminuric diabetic pa

SUBMITTER: Jayakumar C 

PROVIDER: S-EPMC3965190 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature