Absence of tissue factor is characteristic of lymphoid malignancies of both T- and B-cell origin.

ABSTRACT:

Background

Thrombosis is a marker of poor prognosis in individuals with solid tumors. The expression of tissue factor (TF) on the cell surface membrane of malignant cells is a pivotal molecular link between activation of coagulation, angiogenesis, metastasis, aggressive tumor behavior and poor survival. Interestingly, thrombosis is associated with shortened survival in solid, but not in lymphoid neoplasias.

Objectives

We sought to study whether the lack of impact of thrombosis on survival in lymphoid neoplasias could be due to a lack of tumor-derived TF expression.

Methods

We analyzed TF gene (F3) expression in lymphoid (N=114), myeloid (N=49) and solid tumor (N=856) cell lines using the publicly available dataset from the Broad-Novartis Cancer Cell Line Encyclopedia

SUBMITTER: Cesarman-Maus G 

PROVIDER: S-EPMC3965198 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature