Ontology highlight
ABSTRACT:
SUBMITTER: Cao F
PROVIDER: S-EPMC3965208 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Molecular cell 20140102 2
Here we report a comprehensive characterization of our recently developed inhibitor MM-401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically inhibit MLL1 activity by blocking MLL1-WDR5 interaction and thus the complex assembly. This targeting strategy does not affect other mixed-lineage leukemia (MLL) family histone methyltransferases (HMTs), revealing a unique regulatory feature for the MLL1 complex. Using MM-401 and its enantiomer control MM-NC-401, we show ...[more]