Discriminating risk and resilience endophenotypes from lifetime illness effects in familial major depressive disorder.

ABSTRACT:

Importance

The neural systems that confer risk or vulnerability for developing familial depression, and those that protect against or confer resilience to becoming ill, can be disentangled from the effects of prior illness by comparing brain imaging measures in previously ill and never ill persons who have either a high or low familial risk for depression.

Objective

To distinguish risk and resilience endophenotypes for major depression from the effects of prior lifetime illness.

Design, setting, and participants

We used functional magnetic resonance imaging to measure and compare brain function during performance of an attentional, self-regulatory task across a large sample of multigenerational families ascertained specifically to be at either high or low risk for dev

SUBMITTER: Peterson BS 

PROVIDER: S-EPMC3965257 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature