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Lomaiviticin biosynthesis employs a new strategy for starter unit generation.

ABSTRACT: Lomaiviticin biosynthesis is thought to utilize a propionyl starter unit for a type II polyketide synthase (PKS). Discovery of the lomaiviticin (lom) biosynthetic gene cluster suggested an unusual method for starter unit generation involving a bifunctional acyltransferase/decarboxylase (AT/DC) thus far observed only in type I PKS pathways. In vitro biochemical characterization of AT/DC Lom62 confirmed its ability to generate a propionyl-acyl carrier protein (ACP), revealing a new role for this enzymatic activity within natural product biosynthesis.

SUBMITTER: Waldman AJ 

PROVIDER: S-EPMC3965344 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Lomaiviticin biosynthesis employs a new strategy for starter unit generation.

Waldman Abraham J AJ   Balskus Emily P EP  

Organic letters 20140102 2

Lomaiviticin biosynthesis is thought to utilize a propionyl starter unit for a type II polyketide synthase (PKS). Discovery of the lomaiviticin (lom) biosynthetic gene cluster suggested an unusual method for starter unit generation involving a bifunctional acyltransferase/decarboxylase (AT/DC) thus far observed only in type I PKS pathways. In vitro biochemical characterization of AT/DC Lom62 confirmed its ability to generate a propionyl-acyl carrier protein (ACP), revealing a new role for this e  ...[more]

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