Effect of intraoperative high-dose remifentanil on postoperative pain: a prospective, double blind, randomized clinical trial.

ABSTRACT:

Background

Remifentanil, an ultra-short-acting opioid, is widely used for pain control during surgery. However, regular dose (RD) remifentanil exacerbates postoperative pain in a dose-dependent manner. Recent studies suggest that high-dose (HD) remifentanil offers sustained analgesia in experimental studies. We thus hypothesized that intraoperative administration of high-dose remifentanil may attenuate postoperative pain.

Methods

In this prospective, randomized, double blind, controlled clinical study, sixty patients undergoing thyroidectomy (18-60 years-of-age) received an intraoperative infusion of 0.2 (RD group) or 1.2 μg kg(-1) min(-1) (HD group) remifentanil during thyroidectomy. A visual analogue scale (VAS) was used to measure pain intensity. Mechanical pain threshold

SUBMITTER: Zhang YL 

PROVIDER: S-EPMC3965388 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature