Delaying treatment of ocular hypertension: the ocular hypertension treatment study.

ABSTRACT:

Objective

To compare the safety and efficacy of earlier vs later treatment in preventing primary open-angle glaucoma (POAG) in individuals with ocular hypertension.

Methods

One thousand six hundred thirty-six individuals with intraocular pressure (IOP) from 24 to 32 mm Hg in 1 eye and 21 to 32 mm Hg in the fellow eye were randomized to observation or to topical ocular hypotensive medication. Median time of treatment in the medication group was 13.0 years. After a median of 7.5 years without treatment, the observation group received medication for a median of 5.5 years. To determine if there is a penalty for delaying treatment, we compared the cumulative proportions of participants who developed POAG at a median follow-up of 13 years in the original observation group and in t

SUBMITTER: Kass MA 

PROVIDER: S-EPMC3966140 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature