Histotripsy beyond the intrinsic cavitation threshold using very short ultrasound pulses: microtripsy.

ABSTRACT: Histotripsy produces tissue fractionation through dense energetic bubble clouds generated by short, high-pressure, ultrasound pulses. Conventional histotripsy treatments have used longer pulses from 3 to 10 cycles, wherein the lesion-producing bubble cloud generation depends on the pressure-release scattering of very high peak positive shock fronts from previously initiated, sparsely distributed bubbles (the shock-scattering mechanism). In our recent work, the peak negative pressure (P-) for generation of dense bubble clouds directly by a single negative half cycle, the intrinsic threshold, was measured. In this paper, the dense bubble clouds and resulting lesions (in red blood cell phantoms and canine tissues) generated by these supra-intrinsic threshold pulses were studied. A 32-element,

SUBMITTER: Lin KW 

PROVIDER: S-EPMC3966303 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature