A preliminary study of the influence of age of onset and childhood trauma on cortical thickness in major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) neural underpinnings may differ based on onset age and childhood trauma. We assessed cortical thickness in patients who differed in age of MDD onset and examined trauma history influence.

Methods

Adults with MDD (N=36) and controls (HC; N=18) underwent magnetic resonance imaging. Twenty patients had MDD onset<24 years of age (pediatric onset) and 16 had onset>25 years of age (adult onset). The MDD group was also subdivided into those with (N=12) and without (N=19) physical and/or sexual abuse as assessed by the Childhood Trauma Questionnaire (CTQ). Cortical thickness was analyzed with FreeSurfer software.

Results

Thicker frontal pole and a tendency for thinner transverse temporal cortices existed in MDD. The former was driven

SUBMITTER: Jaworska N 

PROVIDER: S-EPMC3966405 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature