Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells.

ABSTRACT:

Background and purpose

Marine sponges have evolved the capacity to produce a series of very efficient chemicals to combat viruses, bacteria, and eukaryotic organisms. It has been demonstrated that several of these compounds have anti-neoplastic activity. The highly toxic sponge Crambe crambe has been the source of several molecules named crambescidins. Of these, crambescidin-816 has been shown to be cytotoxic for colon carcinoma cells. To further investigate the potential anti-carcinogenic effect of crambescidin-816, we analysed its effect on the transcription of HepG2 cells by microarray analysis followed by experiments guided by the results obtained.

Experimental approach

After cytotoxicity determination, a transcriptomic analysis was performed to test the effect of crambe

SUBMITTER: Rubiolo JA 

PROVIDER: S-EPMC3966746 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature