Ontology highlight
ABSTRACT:
SUBMITTER: Zack TI
PROVIDER: S-EPMC3966983 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Nature genetics 20131001 10
Determining how somatic copy number alterations (SCNAs) promote cancer is an important goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas Pan-Cancer data set. Whole-genome doubling, observed in 37% of cancers, was associated with higher rates of every other type of SCNA, TP53 mutations, CCNE1 amplifications and alterations of the PPP2R complex. SCNAs that were internal to chromosomes tended to be shorter than telomere-bounded SCNAs, suggesting different mechanisms ...[more]