Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest.

ABSTRACT:

Background

There is limited information on genetic factors associated with sudden cardiac arrest (SCA).

Objective

To assess the association of common variation in genes in fatty acid pathways with SCA risk.

Methods

We selected 85 candidate genes and 1155 single nucleotide polymorphisms (SNPs) tagging common variation in each gene. We investigated the SNP associations with SCA in a population-based case-control study. Cases (n = 2160) were from a repository of SCA in the greater Seattle area. Controls (n = 2615), frequency-matched on age and sex, were from the same area. We used linear logistic regression to examine SNP associations with SCA. We performed permutation-based p-min tests to account for multiple comparisons within each gene. The SNP associations with a cor

SUBMITTER: Lemaitre RN 

PROVIDER: S-EPMC3966996 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature