Ontology highlight
ABSTRACT:
SUBMITTER: Niu B
PROVIDER: S-EPMC3967115 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Bioinformatics (Oxford, England) 20131225 7
<h4>Motivation</h4>Microsatellite instability (MSI) is an important indicator of larger genome instability and has been linked to many genetic diseases, including Lynch syndrome. MSI status is also an independent prognostic factor for favorable survival in multiple cancer types, such as colorectal and endometrial. It also informs the choice of chemotherapeutic agents. However, the current PCR-electrophoresis-based detection procedure is laborious and time-consuming, often requiring visual inspec ...[more]