Randomized placebo-controlled D-cycloserine with cognitive behavior therapy for pediatric posttraumatic stress.

ABSTRACT:

Unlabelled

Abstract Objective: Research on D-cycloserine (DCS), a partial N-methyl-d-aspartic acid (NMDA) agonist, has suggested that it may enhance exposure-based therapies for anxiety disorders. RESULTS with DCS in adult posttraumatic stress disorder (PTSD) have been conflicting; however, no data have been reported on children with PTSD. Although many individuals with PTSD respond to exposure-based cognitive behavioral therapy (CBT), there are subgroups of individuals who are nonresponders, and many responders still have substantial residual symptoms. This randomized, triple-blind, placebo-controlled study tested DCS as an adjunct to CBT to improve and speed treatment response for PTSD in youth.

Methods

Seven to 18 year-old youth with exposure to trauma and PTSD were offer

SUBMITTER: Scheeringa MS 

PROVIDER: S-EPMC3967356 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature