BDNF Met66 modulates the cumulative effect of psychosocial childhood adversities on major depression in adolescents.

ABSTRACT:

Background

The interplay among lifetime adversities and the genetic background has been previously examined on a variety of measures of depression; however, only few studies have focused on major depression disorder (MDD) in adolescence.

Methods

Using clinical data and DNA samples from mouthwash gathered from an epidemiological study on the prevalence of mental disorders in youths between 12 and 17 years old, we tested the statistical interaction between a set of psychosocial adversities experienced during childhood (CAs) with two common polymorphisms in the brain-derived neurotrophic factor (BDNF) (Val66Met) and SLC6A4 (L/S) genes on the probability of suffering MDD in adolescence.

Results

Genotype or allele frequencies for both polymorphisms were similar between gro

SUBMITTER: Cruz-Fuentes CS 

PROVIDER: S-EPMC3967543 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature