Pharmacologic dissociation between impulsivity and alcohol drinking in high alcohol preferring mice.

ABSTRACT:

Background

Impulsivity is genetically correlated with, and precedes, addictive behaviors and alcoholism. If impulsivity or attention is causally related to addiction, certain pharmacological manipulations of impulsivity and/or attention may affect alcohol drinking, and vice versa. The current studies were designed to explore the relationship among impulsivity, drinking, and vigilance in selectively bred High Alcohol Preferring (HAP) mice, a line that has previously demonstrated both high impulsivity and high alcohol consumption. Amphetamine, naltrexone, and memantine were tested in a delay discounting (DD) task for their effects on impulsivity and vigilance. The same drugs and doses were also assessed for effects on alcohol drinking in a 2-bottle choice test.

Methods

HAP mic

SUBMITTER: Oberlin BG 

PROVIDER: S-EPMC3967789 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature