A discrete model of Drosophila eggshell patterning reveals cell-autonomous and juxtacrine effects.

ABSTRACT: The Drosophila eggshell constitutes a remarkable system for the study of epithelial patterning, both experimentally and through computational modeling. Dorsal eggshell appendages arise from specific regions in the anterior follicular epithelium that covers the oocyte: two groups of cells expressing broad (roof cells) bordered by rhomboid expressing cells (floor cells). Despite the large number of genes known to participate in defining these domains and the important modeling efforts put into this developmental system, key patterning events still lack a proper mechanistic understanding and/or genetic basis, and the literature appears to conflict on some crucial points. We tackle these issues with an original, discrete framework that considers single-cell models that are integrated to constr

SUBMITTER: Faure A 

PROVIDER: S-EPMC3967936 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature