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Comparative analysis of the macroscale structural connectivity in the macaque and human brain.

ABSTRACT: The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.

SUBMITTER: Goulas A

PROVIDER: S-EPMC3967942 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Comparative analysis of the macroscale structural connectivity in the macaque and human brain.

Goulas Alexandros A Bastiani Matteo M Bezgin Gleb G Uylings Harry B M HB Roebroeck Alard A Stiers Peter P

PLoS computational biology 20140327 3

The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but als ...[more]

PMID: 24676052

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Dataset Information

Comparative analysis of the macroscale structural connectivity in the macaque and human brain.

Publications

Comparative analysis of the macroscale structural connectivity in the macaque and human brain.

Similar Datasets

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