Deafness gene expression patterns in the mouse cochlea found by microarray analysis.

ABSTRACT:

Background

Tonotopy is one of the most fundamental principles of auditory function. While gradients in various morphological and physiological characteristics of the cochlea have been reported, little information is available on gradient patterns of gene expression. In addition, the audiograms in autosomal dominant non syndromic hearing loss can be distinctive, however, the mechanism that accounts for that has not been clarified. We thought that it is possible that tonotopic gradients of gene expression within the cochlea account for the distinct audiograms.

Methodology/principal findings

We compared expression profiles of genes in the cochlea between the apical, middle, and basal turns of the mouse cochlea by microarray technology and quantitative RT-PCR. Of 24,547 genes, 7

SUBMITTER: Yoshimura H 

PROVIDER: S-EPMC3967995 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature