How and when should NSAIDs be used for preventing post-ERCP pancreatitis? A systematic review and meta-analysis.

ABSTRACT:

Background

Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be efficacious to prevent pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). However, the target patients, the type of NSAID, the route of administration and the time of drug delivery remain unclear, as well as the potential efficacy in reducing the severity of pancreatitis, length of hospital stay and mortality. The objective of the study was to evaluate these questions by performing a systematic review and meta-analysis.

Methods

Multiple searches were performed in the main databases. Randomized controlled trials (RCTs) comparing NSAIDs vs. placebo in the prevention of post-ERCP pancreatitis were included. Primary endpoint of the study was the efficacy for pancreatitis preven

SUBMITTER: Puig I 

PROVIDER: S-EPMC3968039 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature