Impact of weight loss on ankle-brachial index and interartery blood pressures.

ABSTRACT:

Objective

To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis.

Methods

The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants.

Results

ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; P = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC3968218 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature