Axo-dendritic overlap and laminar projection can explain interneuron connectivity to pyramidal cells.

ABSTRACT: Neocortical GABAergic interneurons have important roles in the normal and pathological states of the circuit. Recent work has revealed that somatostatin-positive (SOM) and parvalbumin-positive (PV) interneurons connect promiscuously to pyramidal cells (PCs). We investigated whether Peters' rule, that is, the spatial overlap of axons and dendrites, could explain this unspecific connectivity. We reconstructed the morphologies of P11-17 mouse SOM and PV interneurons and their PC targets, and performed Monte Carlo simulations to build maps of predicted connectivity based on Peters' rule. We then compared the predicted with the real connectivity maps, measured with 2-photon uncaging experiments, and found no statistical differences between them in the probability of connection as a function of

SUBMITTER: Packer AM 

PROVIDER: S-EPMC3968298 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature