Influence of two depuration periods on the activity and transcription of antioxidant enzymes in tilapia exposed to repeated doses of cylindrospermopsin under laboratory conditions.

ABSTRACT: The cyanobacterial toxin Cylindrospermopsin (CYN), a potent protein synthesis inhibitor, is increasingly being found in freshwater bodies infested by cyanobacterial blooms worldwide. Moreover, it has been reported to be implicated in human intoxications and animal mortality. Recently, the alteration of the activity and gene expression of some glutathione related enzymes in tilapias (Oreochromis niloticus) exposed to a single dose of CYN has been reported. However, little is known about the effects induced by repeated doses of this toxin in tilapias exposed by immersion and the potential reversion of these biochemical alterations after two different depuration periods (3 or 7 days). In the present study, tilapias were exposed by immersion to repeated doses of a CYN-containing culture of Aph

SUBMITTER: Rios V 

PROVIDER: S-EPMC3968377 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature