Bioavailable insulin-like growth factor-I inversely related to weight gain in postmenopausal women regardless of exogenous estrogen.

ABSTRACT:

Background

Weight gain, insulin-like growth factor-I (IGF-I) levels, and excess exogenous steroid hormone use are putative cancer risk factors, yet their interconnected pathways have not been fully characterized. This cross-sectional study investigated the relationship between plasma IGF-I levels and weight gain according to body mass index (BMI), leptin levels, and exogenous estrogen use among postmenopausal women.

Methods

This study included 794 postmenopausal women who enrolled in an ancillary study of the Women's Health Initiative Observational Study between February 1995 and July 1998. The relationship between IGF-I levels and weight gain was analyzed using ordinal logistic regression. We used the molar ratio of IGF-I to IGF binding protein-3 (IGF-I/IGFBP-3) or circulat

SUBMITTER: Jung SY 

PROVIDER: S-EPMC3968542 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature