A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia.

ABSTRACT: Understanding genetic influences on both healthy and disordered brain function is a major focus in psychiatric neuroimaging. We utilized task-related imaging findings from an fMRI auditory oddball task known to be robustly associated with abnormal activation in schizophrenia, to investigate genomic factors derived from multiple single nucleotide polymorphisms (SNPs) from genes previously shown to be associated with schizophrenia. Our major aim was to investigate the relationship of these genomic factors to normal/abnormal brain functionality between controls and schizophrenia patients. We studied a Caucasian-only sample of 35 healthy controls and 31 schizophrenia patients. All subjects performed an auditory oddball task, which consists of detecting an infrequent sound within a series of fr

SUBMITTER: Meda SA 

PROVIDER: S-EPMC3968678 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature