Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects.

ABSTRACT:

Importance

Identifying risk factors for increased β-amyloid (Aβ) deposition is important for targeting individuals most at risk for developing Alzheimer disease and informing clinical practice concerning prevention and early detection.

Objective

To investigate risk factors for Aβ deposition in cognitively healthy middle-aged and older adults. Specifically, we hypothesized that individuals with a vascular risk factor such as hypertension, in combination with a genetic risk factor for Alzheimer disease (apolipoprotein E ε4 allele), would show greater amyloid burden than those without such risk.

Design

Cross-sectional study.

Setting

General community.

Participants

One hundred eighteen well-screened and cognitively normal adults, aged 47 to 89 years. Partici

SUBMITTER: Rodrigue KM 

PROVIDER: S-EPMC3968915 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature