Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery.

ABSTRACT:

Background

The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation are critical determinants of ventricular remodeling in this patient population.

Methods and results

To document the growth kinetics of CSCs, population-doubling time, telomere length, telomerase activity, and insulin-like growth factor-1 receptor expression were measured in CSCs isolated from 38 patients undergoing bypass surgery. Additionally, the blood levels of insulin-like growth factor-1, hepatocyte growth factor, and vascular endothelial growth factor we

SUBMITTER: D'Amario D 

PROVIDER: S-EPMC3969331 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature