Urine stability studies for novel biomarkers of acute kidney injury.

ABSTRACT:

Background

The study of novel urinary biomarkers of acute kidney injury has expanded exponentially. Effective interpretation of data and meaningful comparisons between studies require awareness of factors that can adversely affect measurement. We examined how variations in short-term storage and processing might affect the measurement of urine biomarkers.

Study design

Cross-sectional prospective.

Setting & participants

Hospitalized patients from 2 sites: Yale New Haven Hospital (n=50) and University of California, San Francisco Medical Center (n=36).

Predictors

We tested the impact of 3 urine processing conditions on these biomarkers: (1) centrifugation and storage at 4°C for 48 hours before freezing at -80°C, (2) centrifugation and storage at 25°C for 48 hours

SUBMITTER: Parikh CR 

PROVIDER: S-EPMC3969397 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature