Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.

ABSTRACT: During meiotic prophase I, interactions between maternal and paternal chromosomes, under checkpoint surveillance, establish connections between homologs that promote their accurate distribution to meiotic progeny. In human, faulty meiosis causes aneuploidy resulting in miscarriages and genetic diseases. Meiotic processes occur in the context of chromatin; therefore, histone post-translational modifications are expected to play important roles. Here, we report the cytological distribution of the evolutionarily conserved DOT1L methyltransferase and the different H3K79 methylation states resulting from its activity (mono-, di- and tri-methylation; H3K79me1, me2 and me3, respectively) during meiotic prophase I in mouse spermatocytes. In the wild type, whereas low amounts of H3K79me1 are rather

SUBMITTER: Ontoso D 

PROVIDER: S-EPMC3969405 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature